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KMID : 1156220220480060324
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Journal of Environmental Health Sciences
2022 Volume.48 No. 6 p.324 ~ p.360
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Affecting Factors of Lung Disease and Classification of Exposure Rating of Applicants for Injuries from Humidifier Disinfectants
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Min Gi-Hong
Shin Jung-Hyun
Jo Eun-Kyung
Jeong Da-Young
Ryu Ji-Yoon
Kim Dong-Jun
Woo Jae-Min
Bae Sung-Ho
Shin Ji-Hun
Lee Seul-A
Choi Yoon-Hyeong
Yang Won-Ho
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Abstract
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Background: Lung injuries due to exposure to humidifier disinfectants (HDs) were reported in 2011 in South Korea. As a result of the government’s epidemiological investigation and toxicity test study, it was found that HDs caused health damage such as lung disease.
Objectives: The purpose of this study was to classify HD exposure ratings and analyze the affecting factors that could identify the relationship with lung disease.
Methods: Exposure assessment for HDs was conducted using a questionnaire during face-to-face interviews with the applicants. Ratings of high exposure (Class 1) and low exposure (Class 2) were cross-tabulated with clinical ratings (acceptable and unacceptable). Logistic regression analysis was carried out by setting the clinical rating of lung disease as a dependent variable and the socio-demographic and exposure characteristics obtained through the questionnaire as independent variables.
Results: The concentration in air of polyhexamethylene guanidine (PHMG) was 71.96±107.47 μg/m3, and the exposure concentration was 15.21±23.28 μg/m3. The exposure rating was overestimated with 97.1% of affected subjects having high exposure using margin of exposure (MOE), but only 9.9% matching the clinical class. In the overestimated group, it could be explained by the fact that the exposure time was long and the subjects had already recovered from damage symptoms. As a result of logistic regression analysis, ten variables were found to be significant inf luencing factors.
Conclusions: A new exposure rating could be calculated based on the MOE, and factors affecting lung disease could be estimated through comparative evaluation with the clinical rating.
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KEYWORD
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Humidifier disinfectant, exposure rating, margin of exposure, lung disease
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